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Nijagal Lab »  People »  Post-Doctoral Fellows »  Rebeca De Paiva Froes Rocha, Ph.D.
Rebeca De Paiva Froes Rocha, Ph.D. (she/her)

Rebeca De Paiva Froes Rocha, Ph.D. (she/her)

  • Postdoctoral Scholar

Contact Information

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Education

Federal University of Minas Gerais, Laboratory of Immunopharmacology, Belo Horizonte, Brazil, B.S., Biological Sciences, 2016

Federal University of Minas Gerais, Laboratory of Immunopharmacology, Belo Horizonte, Brazil, M.S., Biochemistry and Immunology, 2017

Universidade Estadual de Campinas & the Brazilian Biosciences National Laboratory, Brazil, Ph.D., Genetics and Molecular Biology, 2022

Residencies

  • The Scripps Research Institute, Department of Structural Biology, La Jolla, California, 2020-2021

Postdoctoral Training

  • University of California, San Francisco, 2022 - Present

Biography

Rebeca started at the Laboratory of Immunopharmacology at the Federal University of Minas Gerais in 2011 during her undergraduate years. Since then, she has focused on projects related to arboviruses and the host's immune response. After obtaining a Bachelor's degree in Biological Sciences from the same university in 2016, Rebeca pursued a Master's degree in Biochemistry and Immunology. In 2017, with her Master's degree completed, she began a Ph.D. in Genetics and Molecular Biology at Universidade Estadual de Campinas (UNICAMP), stationed at the Brazilian Biosciences National Laboratory (LNBio). With a specialization in Immunopharmacology and Microbiology, particularly in Virology, Rebeca then joined the Nijagal Lab as a postdoc, further enriching her scientific journey. At present, she is fortunate to have the support of the Pew Fellowship, enabling her to deeply explore the effects of inflammation within the maternal-fetal interplay and its potential implications for the development of pediatric malignancies.

Books Chapters & Edited Books

  1. Costa, VV; Fagundes, CT; Valadão, DF; Ávila, TV; Cisalpino, D; Rocha, RPF; Ribeiro, LS; Ascenção, FR; Kangussu, LM; Junior, CMQ; Astigarraga, RG; Gouveia, FL; Silva, TA; Bonaventura, D; De Almeida Sampaio, D; Leite, ACL; Teixeira, MM; Souza, DG. Subversion of early innate antiviral responses during antibody dependent enhancement of Dengue virus infection induces severe disease in immunocompetent mice. Medical Microbiology and Immunology. v.203, p.231 250, 2014. doi:10.1007/s0043001403345
  2. Marques, RE.; Guabiraba, R Del Sarto, JL.; Rocha, RPF.; Queiroz, AL; Cisalpino, D; Marques, PE.; Pacca, CC; Fagundes, CT; Menezes, GB; Nogueira, ML; Souza, DG; Teixeira, MM. Dengue virus requires the C-C chemokine receptor CCR5 for replication and infection development. Immunology (Oxford. Print)., v.145, p.583 596, 2015. doi:10.1111/imm.12476
  3. Costa, VV.; Del Sarto, JL; Rocha, RPF.; Silva, FR.; Doria, JG.; Olmo, IG.; Marques, RE; Queiroz Jr., CM.; Foureaux, G; Araújo, JMS.; Cramer, A; Real, ALCV; Ribeiro, LS; Sardi, SI; Ferreira, AJ; Machado, FS; Deoliveira, AC.; Teixeira, AL; Nakaya, HI; Souza, DG; Ribeiro, FM.; Teixeira, MM. N-Methyl-D-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection. mBio., v.8, p.e0035017, 2017. doi:10.1128/mbio.0035017
  4. Rocha, RPF; Del Sarto, JL; Marques, RE; Costa, VV; Teixeira, MM. Host target-based approaches against arboviral diseases. Biological Chemistry. Biological Chemistry, v. 0, n. 0, 27 nov. 2017. doi.org/10.1515/hsz-2017-0236
  5. Marques, RE; Rocha, RPF.*; Del Sarto, JL*; Gomes, GF.; Cramer, A; Rachid, MA.; Souza, DG.; Nogueira, ML.; Teixeira, MM. Development of a model of Saint Louis encephalitis infection and disease in mice. Journal of Neuroinflammation, v.14, p.12, 2017. doi:10.1186/s1297401708372 *Authors contributed equally to this work
  6. Terzian, ACB; Zini, N; Sacchetto, L; Rocha, RPF; Parra, MCP; Del Sarto, JL; Dias, ACF; Coutinho, F; Rayra, J; Da Silva, RA; Costa, VV; Fernandes, NCCA; Réssio, R; Díaz-Delgado, J; Guerra, J; Cunha, MS.; Catão-Dias, JL; Bittar, C; Reis, AFN; Santos, INPD; Ferreira, ACM; Cruz, LEAA; Rahal, P; Ullmann, L; Malossi, C; Araújo Jr, JP; Widen, S; De Rezende, IM; Mello, E; Pacca, CC; Kroon, EG; Trindade, G; Drumond, B; Chiaravalloti-Neto, F; Vasilakis, N; Teixeira, MM; Nogueira, ML. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. Scientific Reports. v.8, p.16034 - , 2018. doi:10.1038/s41598-018-34423-6
  7. Rocha, RPF; Del Sarto, JL; Gomes, GF; Gonçalves, MP; Rachid, MA; Smetana, JHC; Souza, DG; Teixeira, MM; Marques, RE. Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain. Virulence. 2019 JCR: v.12, p.244 - 259, 2021.
  8. Rocha, RPF*; Del Sarto, JL*; Bassit, L; Olmo, IG; Valiate, B; Queiroz-Junior, CM; Pedrosa, CSG; Ribeiro, FM; Guimarães, MZ; Rehene, S; Amblardb, F; Zhou, L; Cox, BD; Gavegnano, C; Costa, VV; Schinazi, RF; Teixeira, MM 7-Deaza-7-Fluoro-2'-C- Methyladenosine Inhibits Zika virus Infection and viral-induced Neuroinflammation. Antiviral Res. 2020 Aug; 180:104855. Epub 2020 Jun 20. doi:10.1016/j.antiviral.2020.104855. *Authors contributed equally to this work
  9. Ribeiro-Filho HV, Coimbra LD, Cassago A, Rocha RPF, Guerra JVDS, de Felicio R, Carnieli CM, Leme L, Padilha AC, Paes Leme AF, Trivella DBB, Portugal RV, Lopes-de-Oliveira PS, Marques RE. Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses. Nat Commun. 2021 May 24;12(1):3038. doi: 10.1038/s41467-021-23400-9.
  10. Fontoura MA, Rocha RPF, Marques RE. Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection. Life (Basel). 2021 Jul 20;11(7):717. doi: 10.3390/life11070717.
  11. Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Peña AT,
  12. Rocha RPF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nat Commun. 2021 Aug 10;12(1):4817. doi: 10.1038/s41467-021-25087-4
  13. Naciuk, Fabrício Fredo; Nascimento, Andrey Fabricio Ziem; Rocha, Rebeca Paiva Froes; Rustiguel, Joane Kathelen; Coimbra, Lais Durço; Marques, Rafael Elias; Bruder, Marjorie. Competing interests during the key N-glycosylation of 6-chloro-7-deaza-7-iodopurine for the synthesis of 7-deaza-2--methyladenosine using Vorbrüggen conditions. Frontiers in Chemistry. v.11, p.10076608-,2023. Referências adicionais: Home page: [doi:10.3389/fchem.2023.1163486]
  14. De Carvalho, Ana Carolina; Dias, Carlos Sato B.; Coimbra, Laís D.; Rocha, Rebeca P. F.; Borin, Alexandre; Fontoura, Marina A.; Carvalho, Murilo; Proost, Paul; Nogueira, Maurício L.; Consonni, Sílvio R; Sesti-Costa, Renata; Marques, Rafael Elias. Characterization of Systemic Disease Development and Paw Inflammation in a Susceptible Mouse Model of Mayaro Virus Infection and Validation Using X-ray Synchrotron Microtomography. International Journal Of Molecular Sciences.,v.24,p.4799-,2023 home page:[doi:10.3390/ijms24054799]
  15. Torrents De La Peña, Alba; Sewall, Leigh M.; De Paiva Froes Rocha, Rebeca; Jackson, Abigail M.; Pratap, Payal P.; Bangaru, Sandhya; Cottrell, Christopher A.; Mohanty, Subhasis; Shaw, Albert C.; Ward, Andrew B. Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell Reports Methods. v.1, p.100509 ,2023.[https://doi.org/10.1016/j.crmeth.2023.100509] *Authors contributed equally to this work
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